Amino Acid Profile
The determination of the concentration of free amino acids in blood samples provides new, precise insights into individual health status


The importance of amino acids
Free amino acids in the blood are more readily available for use by the body than protein-bound forms.
Rapid absorption
Transport
Metabolism
Regulation
The analysis of the concentration of free amino acids can be helpful for
Nutritional assessment and identifying possible nutrient deficiencies
Monitoring the function of organs and organ systems
Medical diagnostics to identify certain health conditions, including metabolic disorders, and to monitor recovery
Amino acid deficiency
Malnutrition is commonly observed in the elderly and individuals with poor protein intake, such as vegetarians and vegans. This can lead to various health issues.
Gastrointestinal diseases, including leaky gut and malabsorption, are often associated with malnutrition. Glutamine is crucial for maintaining gut lining health.
Sarcopenia refers to the loss of muscle mass and strength that exceeds the normal age-related decline. Deficiency in leucine, isoleucine, and valine, is a common trigger for sarcopenia in old age.
The amino acids lysine and threonine are crucial building blocks for the formation of antibodies, which play a significant role in strengthening the immune system and fighting infections.
Glutamine is a vital amino acid that promotes a relaxed mental state by playing important roles in neurotransmitter synthesis and brain function.
The most common symptom of Long-Covid is exhaustion or fatigue, which may be due to the undersupply of amino acids to mitochondria, the powerhouses of cells that are essential for energy metabolism and optimal body performance.
Elevated level of amino acid
Such aminoacidopathy can be associated with diseases such as liver cirrhosis and NAFL (especially tyrosine, methionine).
Elevated isoleucine, leucine and valine levels may be signs of fasting.
Interactive Amino Acid Emulator


Individuals who may benefit from lifespin® Amino Acid Profile
- Acutely and chronically ill individuals, who depend on a functioning immune system.
- Elderly who may have difficulty absorbing or utilizing dietary protein.
- Vegetarians or vegans, who may have limited dietary sources of certain amino acids.
- Athlets or bodybuilders, who engage in highintensity exercise.
The lifespin® Amino Acid Profile*
- Alanine
- Arginine
- Asparagine
- Aspartic acid
- Glutamine
- Glutamic acid
- Glycine
- Histidine
- Isoleucine
- Leucine
- Lysine
- Methionine
- Phenylalanine
- Proline
- Serine
- Threonine
- Tyrosine
- Valine
- 1-Methylhistidine
- 3-Methylhistidine
- Betaine
- Cystine
- Creatinine
- Dimethylglycine
- Ornithine
- Sarcosine
With lifespin, this is What You Get:
up to 100x more Health Data
Benefits
Blood
ad10x*
cost
ad100x*
Speed
ad1000x*
data
ad100x*
Recurring Analysis
Revenue Stream
The lifespin® Workflow

The lifespin®
Amino Acid Profile Report*
Amino Acid |
Result (mmol/l) |
Reference Range (mmol/l) |
---|---|---|
Arginine | 0.074 | 0 - 0.224 |
+ Isoleucine | 0.146 | 0.033 - 0.123 |
- Tyrosine | 0.037 | 0.041 - 0.106 |
Product Application
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References
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Chen, Jinna, Shulei Zhang, Jiaxiong Wu, Shiyuan Wu, Gaosheng Xu, und Dangheng Wei. 2019. „Essential Role of Nonessential Amino Acid Glutamine in Atherosclerotic Cardiovascular Disease“. DNA and Cell Biology 39 (1): 8–15. https://doi.org/10.1089/dna.2019.5034.
Chen, Tianlu, Yan Ni, Xiaojing Ma, Yuqian Bao, Jiajian Liu, Fengjie Huang, Cheng Hu, u. a. 2016. „Branched-Chain and Aromatic Amino Acid Profiles and Diabetes Risk in Chinese Populations“. Scientific Reports 6 (Februar): 20594. https://doi.org/10.1038/srep20594.
Dereziński, Paweł, Agnieszka Klupczynska, Wojciech Sawicki, Jerzy A. Pałka, und Zenon J. Kokot. 2017. „Amino Acid Profiles of Serum and Urine in Search for Prostate Cancer Biomarkers: A Pilot Study“. International Journal of Medical Sciences 14 (1): 1–12. https://doi.org/10.7150/ijms.15783.
Grajeda-Iglesias, Claudia, und Michael Aviram. 2018. „Specific Amino Acids Affect Cardiovascular Diseases and Atherogenesis via Protection against Macrophage Foam Cell Formation: Review Article“. Rambam Maimonides Medical Journal 9 (3). https://doi.org/10.5041/RMMJ.10337.
Hakuno, Daihiko, Yasuhito Hamba, Takumi Toya, und Takeshi Adachi. 2015. „Plasma Amino Acid Profiling Identifies Specific Amino Acid Associations with Cardiovascular Function in Patients with Systolic Heart Failure“. PLOS ONE 10 (2): e0117325. https://doi.org/10.1371/journal.pone.0117325.
Ishikawa, Toru. 2012. „Branched-Chain Amino Acids to Tyrosine Ratio Value as a Potential Prognostic Factor for Hepatocellular Carcinoma“. World Journal of Gastroenterology 18 (17): 2005–8. https://doi.org/10.3748/wjg.v18.i17.2005.
Jiang, Lihua, Meng Wang, Shin Lin, Ruiqi Jian, Xiao Li, Joanne Chan, Guanlan Dong, u. a. 2020. „A Quantitative Proteome Map of the Human Body“. Cell 183 (1): 269-283.e19. https://doi.org/10.1016/j.cell.2020.08.036.
Ruiz-Canela, Miguel, Estefania Toledo, Clary B. Clish, Adela Hruby, Liming Liang, Jordi Salas-Salvadó, Cristina Razquin, u. a. 2016. „Plasma Branched-Chain Amino Acids and Incident Cardiovascular Disease in the PREDIMED Trial“. Clinical Chemistry 62 (4): 582–92. https://doi.org/10.1373/clinchem.2015.251710.
Scoville, Elizabeth A., Margaret M. Allaman, Caroline T. Brown, Amy K. Motley, Sara N. Horst, Christopher S. Williams, Tatsuki Koyama, u. a. 2018. „Alterations in Lipid, Amino Acid, and Energy Metabolism Distinguish Crohn’s Disease from Ulcerative Colitis and Control Subjects by Serum Metabolomic Profiling“. Metabolomics 14 (1): 17. https://doi.org/10.1007/s11306-017-1311-y.
Tobias, Deirdre K., Patrick R. Lawler, Paulo H. Harada, Olga V. Demler, Paul M. Ridker, JoAnn E. Manson, Susan Cheng, und Samia Mora. 2018. „Circulating Branched-Chain Amino Acids and Incident Cardiovascular Disease in a Prospective Cohort of US Women“. Circulation. Genomic and Precision Medicine 11 (4): e002157. https://doi.org/10.1161/CIRCGEN.118.002157.
Tobias, Deirdre K., Samia Mora, Subodh Verma, und Patrick R. Lawler. 2018. „Altered Branched Chain Amino Acid Metabolism: Towards a Unifying Cardiometabolic Hypothesis“. Current opinion in cardiology 33 (5): 558–64. https://doi.org/10.1097/HCO.0000000000000552
Yanagisawa, Ryoji, Masaharu Kataoka, Takumi Inami, Yuichi Momose, Takashi Kawakami, Makoto Takei, Mai Kimura, u. a. 2015. „Usefulness of Circulating Amino Acid Profile and Fischer Ratio to Predict Severity of Pulmonary Hypertension“. The American Journal of Cardiology 115 (6): 831–36. https://doi.org/10.1016/j.amjcard.2014.12.048.
Zhao, Xue, Qing Han, Yujia Liu, Chenglin Sun, Xiaokun Gang, und Guixia Wang. 2016. „The Relationship between Branched-Chain Amino Acid Related Metabolomic Signature and Insulin Resistance: A Systematic Review“. Journal of Diabetes Research 2016. https://doi.org/10.1155/2016/2794591.